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- W2365617706 abstract "Objective To explore the effects of IL12 on the splenic lymphocyte proliferation in mice with bloodstage Plasmodium berghei infection. Methods Each of BALB/c mice was infected with 5×10 5 RBC infected P. berghei and administrated with doses 0.03 or 0.15 μg/d of IL12 on the day of infection and daily for 6 days postinfection. The splenic lymphocyte proliferation was determined by 3 HTdR incorporation. Percentages of CD4 + and CD8 + T cells were detected using flow cytometry. Results Following IL12 administration, the mice treated with both doses 0.03 μg/d and 0.15 μg/d showed profound increasing in the number of splenic lymphocyte, as well as profound increasing in the absolute number and percentage of CD4 + and CD8 + T cells. Interestingly, treating with doses 0.03 μg/d of IL12 could significantly enhance splenic lymphocyte proliferative responses. In contrast, a 0.15 μg/d dose significantly inhibited lymphocyte proliferation. Conclusion Appropriate dose of IL12 regulated the development of resistance to P. berghei infection by enhancing splenic lymphocyte proliferative responses. But, higher doses of IL12 significantly inhibited lymphocyte proliferation, which may be detrimental to resistance against P. berghei infection." @default.
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- W2365617706 date "2005-05-08" @default.
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- W2365617706 title "EFFECTS OF IL-12 ON THE SPLENIC LYMPHOCYTE PROLIFERATION IN MICE WITH BLOOD STAGE PLASMODIUM BERGHEI INFECTION" @default.
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