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- W2365619237 abstract "Objective To observe the variations of nuclear factor-κB p65(NF-κB p65) and cytochrome C oxidase-Ⅱ(COX-Ⅱ) in rat models of acute liver failure(ALF).Methods Forty male Sprague-Dawley rats were divided into 5 groups:control group,ALF 4-hour group,ALF 8-hour group,ALF 12-hour group,and ALF 24-hour group.All the ALF rats were given 800 mg/kg of D-galactosamine(D-GalN) and 100 g/kg of lipopolysaccharide(LPS) via intraperitoneal(i.p.) injection to establish the ALF model,and the rats in the control group were given 1 ml of 0.9% saline via i.p.injection.Serum alanine aminotransferase,aspartate aminotrans-ferase,total bilirubin,albumin,prothrombin time,prothrombin activity were examined and rat liver pathological changes were observed in each group.Hepatic NF-κB p65 mRNA levels were examined by real time fluorescent quantitative PCR method.Hepatic mitochondrial COX-Ⅱ activities were examined by spectrophotometry.Results Light microscopic examination showed obvious hepatocyte apoptosis in ALF 8-hour group,and obvious hepatocyte necrosis in ALF 12-hour and 24-hour groups.Hepatic NF-κB p65 mRNA levels in ALF 8-hour,ALF 12-hour and ALF 24-hour groups were lower than those in the control group(P0.001),and the levels in ALF 24-hour group were the lowest.Activities of COX-Ⅱ in ALF rats began to increase at 4 hour,reached a peak at 8 hour(P =0.008,compared with the control group),began to decrease at 12 hour,and decreased more obviously at 24 hour.Conclusions In ALF rats,hepatic NF-κB p65 mRNA levels decrease,while hepatic mitochondrial COX-Ⅱ activities increase in apoptosis phase and decrease later.Both NF-κB p65 and COX-Ⅱ participate in hepatocyte apoptosis in ALF,while NF-κB p65 possibly inhibits hepatocyte regeneration." @default.
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- W2365619237 date "2011-01-01" @default.
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- W2365619237 title "Variations and significance of nuclear factor-κB p65 and cytochrome C oxidase-II in acute liver failure rat models" @default.
- W2365619237 hasPublicationYear "2011" @default.
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