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- W2365625612 abstract "Objective To review the clinical feature,prophylaxis and therapy of glucocorticoid-induced osteoporosis(GIOP).Methods The domestic and abroad literatures of the last 10 years were reviewed to investigate the clinical feature,prophylaxis and therapy of GIOP.Results The therapies with prednisone more than 7.5 mg/day always accompanied with noticeable bone loss.Most severe bone loss(5% to 15%) occurs in the first 6 months from utilization of glucocorticoid.Bone mineral density of cancellous bone predominant decreased.Compression fracture of centrum vertebrae in patients with GIOP obviously increased.Therapy with vitamin D plus calcium had prophylactic effect for the cancellous bone loss in patients with GIOP.Diphosphate can raise bone mineral density of cancellous bone,it almost could be used in all the patients with GIOP including young people and patients who had been treated with hormone replaced therapy.Prophylactic application of calcitonin can not improve bone mineral density of cancellous bone,but remedial application of calcitonin can.Conclusion Therapy with vitamin D plus calcium is the basic measure for prophylaxis of GIOP.Diphosphate has both prophylactic and therapeutic action and can be used as first step drug.Calcitonin can be used as second step drug for the therapy of GIOP,it always be used in patients who are not tolerant with diphosphate or hormone replaced therapy." @default.
- W2365625612 created "2016-06-24" @default.
- W2365625612 creator A5066979645 @default.
- W2365625612 date "2009-01-01" @default.
- W2365625612 modified "2023-09-24" @default.
- W2365625612 title "Prophylaxis and Therapy of Glucocorticoid-induced Osteoporosis" @default.
- W2365625612 hasPublicationYear "2009" @default.
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