FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2365628681> ?p ?o ?g. }

• W2365628681 abstract "In the present study, IFN-γ (Th1), IL-17A (Th17) and IL-4 (Th2) concentrations in response to concanavalin (ConA) and Neospora caninum antigen (Nc-1) stimulation were determined in cultures of cells from control uninfected (n=4), naturally N. caninum-infected (n=3) and experimentally N. caninum-infected (n=6) pregnant dams and their foetuses. Experimental animals were infected at 110days of gestation and euthanized 6weeks post-infection. In culture supernatants from the dams, significantly higher IFN-γ and IL-4 levels were found in the experimentally-infected animals compared to the control or naturally-infected dams. However, among the experimentally-infected dams no significant differences in IFN-γ production were observed regardless of the incidence of live or aborted/dead foetuses, though spleen cultures of dams carrying live foetuses showed the highest levels of IFN-γ. IL-17A production was very low and occasional in the dams infected with N. caninum and did not seem to be a major regulator of IFN-γ production in this model. Experimentally infected dams with live foetuses showed higher IL-4 levels and accordingly IFN-γ/IL-4 ratios were significantly lower than ratios recorded for cows with aborted/dead foetuses. In the infected foetuses of these dams, only spleen cultures showed high levels of IFN-γ and IL-4 after Nc-1 antigen and ConA stimulation, respectively. No IL-17A was detected in the foetuses. As conclusion, although we could not clearly relate a protective immune response against N. caninum abortion only to IFN-γ levels in cell cultures, our results highlight the important role of an inverse IFN-γ/IL-4 balance in conferring protection against abortion induced by this parasite." @default.
• W2365628681 created "2016-06-24" @default.
• W2365628681 creator A5005353960 @default.
• W2365628681 creator A5010767989 @default.
• W2365628681 creator A5024070070 @default.
• W2365628681 creator A5033244482 @default.
• W2365628681 creator A5041208946 @default.
• W2365628681 creator A5060988116 @default.
• W2365628681 creator A5065812390 @default.
• W2365628681 creator A5080850839 @default.
• W2365628681 date "2016-08-01" @default.
• W2365628681 modified "2023-10-17" @default.
• W2365628681 title "Maternal and foetal cytokine production in dams naturally and experimentally infected with Neospora caninum on gestation day 110" @default.
• W2365628681 cites W1550156456 @default.
• W2365628681 cites W1966725363 @default.
• W2365628681 cites W1968813066 @default.
• W2365628681 cites W1973107417 @default.
• W2365628681 cites W1974205861 @default.
• W2365628681 cites W1977251365 @default.
• W2365628681 cites W1977722217 @default.
• W2365628681 cites W1985131511 @default.
• W2365628681 cites W1987912134 @default.
• W2365628681 cites W1994958449 @default.
• W2365628681 cites W1996141879 @default.
• W2365628681 cites W1996518136 @default.
• W2365628681 cites W2007160677 @default.
• W2365628681 cites W2007244628 @default.
• W2365628681 cites W2008759780 @default.
• W2365628681 cites W2010023292 @default.
• W2365628681 cites W2021410932 @default.
• W2365628681 cites W2029999218 @default.
• W2365628681 cites W2031934051 @default.
• W2365628681 cites W2034652100 @default.
• W2365628681 cites W2036190176 @default.
• W2365628681 cites W2039135956 @default.
• W2365628681 cites W2041001602 @default.
• W2365628681 cites W2041192397 @default.
• W2365628681 cites W2042338719 @default.
• W2365628681 cites W2048744684 @default.
• W2365628681 cites W2051881983 @default.
• W2365628681 cites W2052112156 @default.
• W2365628681 cites W2053951514 @default.
• W2365628681 cites W2062629851 @default.
• W2365628681 cites W2070714089 @default.
• W2365628681 cites W2076929821 @default.
• W2365628681 cites W2086031854 @default.
• W2365628681 cites W2088533921 @default.
• W2365628681 cites W2091420565 @default.
• W2365628681 cites W2096863698 @default.
• W2365628681 cites W2098592133 @default.
• W2365628681 cites W2107334859 @default.
• W2365628681 cites W2131321191 @default.
• W2365628681 cites W2134349829 @default.
• W2365628681 cites W2141218723 @default.
• W2365628681 cites W2141510715 @default.
• W2365628681 cites W2147147673 @default.
• W2365628681 cites W2150898460 @default.
• W2365628681 cites W2161791171 @default.
• W2365628681 cites W2163795887 @default.
• W2365628681 cites W2167538262 @default.
• W2365628681 cites W2167948293 @default.
• W2365628681 cites W2188073966 @default.
• W2365628681 cites W2279672789 @default.
• W2365628681 cites W2293883766 @default.
• W2365628681 cites W2411668510 @default.
• W2365628681 doi "https://doi.org/10.1016/j.rvsc.2016.05.003" @default.
• W2365628681 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27473975" @default.
• W2365628681 hasPublicationYear "2016" @default.
• W2365628681 type Work @default.
• W2365628681 sameAs 2365628681 @default.
• W2365628681 citedByCount "7" @default.
• W2365628681 countsByYear W23656286812016 @default.
• W2365628681 countsByYear W23656286812017 @default.
• W2365628681 countsByYear W23656286812018 @default.
• W2365628681 countsByYear W23656286812020 @default.
• W2365628681 crossrefType "journal-article" @default.
• W2365628681 hasAuthorship W2365628681A5005353960 @default.
• W2365628681 hasAuthorship W2365628681A5010767989 @default.
• W2365628681 hasAuthorship W2365628681A5024070070 @default.
• W2365628681 hasAuthorship W2365628681A5033244482 @default.
• W2365628681 hasAuthorship W2365628681A5041208946 @default.
• W2365628681 hasAuthorship W2365628681A5060988116 @default.
• W2365628681 hasAuthorship W2365628681A5065812390 @default.
• W2365628681 hasAuthorship W2365628681A5080850839 @default.
• W2365628681 hasConcept C147483822 @default.
• W2365628681 hasConcept C159654299 @default.
• W2365628681 hasConcept C16685009 @default.
• W2365628681 hasConcept C19869320 @default.
• W2365628681 hasConcept C202751555 @default.
• W2365628681 hasConcept C203014093 @default.
• W2365628681 hasConcept C2778128430 @default.
• W2365628681 hasConcept C2779234561 @default.
• W2365628681 hasConcept C2779357504 @default.
• W2365628681 hasConcept C2780841837 @default.
• W2365628681 hasConcept C2780931953 @default.
• W2365628681 hasConcept C2781154746 @default.
• W2365628681 hasConcept C46973012 @default.
• W2365628681 hasConcept C54355233 @default.
• W2365628681 hasConcept C55493867 @default.
• W2365628681 hasConcept C71924100 @default.

• next