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- W2365639909 abstract "Objective To investigate the effect of interleukin 6 (IL 6) gene on the immune response to HIV gp120 gene. Methods Construction of nucleic vaccine plasmid of HIV 1 CN gp120 gene and IL 6 gene and expression were detected in mammalian cells .The two plasmids were co injected into tibilias anterior muscles of Balb/c mice.Results IFA showed that the constructed plasmids were successfully expressed in mammalian cells. Mice immunized with both gp120 gene and IL 6 gene exhibited a significant increase in number of CD4 +and CD8 +T and the CTL response compared to the mice immunized only with pGP.Conclusion HIV 1 CN gp120 antigen can be enhanced when HIV 1 CN gp120 gene and IL 6 gene are co injected." @default.
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- W2365639909 date "2002-01-01" @default.
- W2365639909 modified "2023-09-25" @default.
- W2365639909 title "Construction and immune response on nucleic vaccine plasmid of HIV-1_(CN) gp120 gene and IL-6 gene in mice" @default.
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