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- W2365641182 abstract "Objective To investigate the changes of serum cardiac troponin I(cTnI)and brain natriuretic peptide(BNP)in heart failure of children with pneumonia and their relationship with heart function.Methods Thirty healthy children aged from 5 months to 3 years old were randomly selected with 17 male and 13 female(healthy group).Thirty children with severe heart failure aged from 3 months to 2 years old were selected at the same time with 21 male and 9 female(heart failure group).Thirty children with ordinary pneumonia aged from 3 months to 3 years old were also sampled with 16 male and 14 female(ordinary pneumonia group).The peripheral bloods of 2-3 mL of all children were taken.The BNP level were measured by enzyme-linked immunosorbent assay and the cTnI level was determined by micro-particle enzyme immunoluminescent.Left ventricular ejection fraction(LVEF) and left ventricular fractional shor-tening(LVFS)were detected by echocardiography.SPSS 11.0 software was used to analyze the data.Results The levels of cTnI [(0.389±0.030) μg/L] and BNP [(0.572±0.090) μg/L] of heart failure group increased significantly compared with healthy and ordinary pneumonia group,while their LVEF and LVFS decreased significantly(Pa0.05).There were linear negative correlation not only between cTnI and LVEF but also between cTnI and LVFS in heart failure group(r=0.87,-0.76 Pa0.05).Similarly,there were linear negative correlation exists not only between BNP and LVEF but also between BNP and LVFS in heart failure group(r=0.97,-0.85 Pa0.05).Conclusion Serum cTnI and BNP can be used as index evaluating the myocardial damage and cardiac dysfunction in pediatric heat failure with pneumonia." @default.
- W2365641182 created "2016-06-24" @default.
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- W2365641182 date "2008-01-01" @default.
- W2365641182 modified "2023-09-27" @default.
- W2365641182 title "Changes of Serum Cardiac Troponin I and Brain Natriuretic Peptide in Pediatric Heart Failure with Pneumonia and Their Relationship with Heart Function" @default.
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