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- W2365641386 abstract "Objective To investigate the activation of nuclear factor kappa B and its significance in Wistar rat brain after focal cerebral ischemia/reperfusion.Methods A rat model of focal cerebral ischemia/reperfusion was made by filament occlusion of the right middle cerebral artery.At 3,6,12 and 24hours post-reperfusion,the cells with NF-κB nuclear translocation in rat brain were determined by immunohistochemistry.Results The level of NF-κB activation was relatively low,but the phenomenon of NF-κB nuclear translocation could be observed throughout brain in normal rats.There was an increase tendency in positive cells with NF-κB nuclear translocation at the R3h between I/Rsub-group and normal control group(P0.05).And there was an obvious increase at the R6h (P0.05),peaking at the R12h (P0.05),and a sharp decrease at the R24h of I/R sub-group until approximately to the normal level(P0.05).Conclusion Focal cerebral ischemia/reperfusion promotes the activation of NF-κB in the ischemic brain tissue which maybe play a neurodegeration role during cerebral ischemia/reperfusion injury." @default.
- W2365641386 created "2016-06-24" @default.
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- W2365641386 date "2003-01-01" @default.
- W2365641386 modified "2023-09-24" @default.
- W2365641386 title "The phenomenon of nuclear factor-κB nuclear translocation and its significance in brain tissue of Wistar rats subjected to focal cerebral ischemia/reperfusion" @default.
- W2365641386 hasPublicationYear "2003" @default.
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