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- W2365657974 abstract "Objective To determine the level of B lymphocyte stimulators (Blys) in peripheral blood plasma from patients with B cell malignancies (multiple myeloma, B-cell non-Hodgkin lymphoma), and investigate the relationship between the level of Blys in plasma and B cell malignancies (MM, B-NHL). Methods The level of Blys in plasma from patients with MM(n=12) and B-NHL (n=31) and healthy volunteers (n=30) were measured respectively with enzyme-linked immunosorbent assay(ELISA). Moreover the level of Blys was compared not only in different phenotypes of B-NHL but also between before and after chemotherapy. Results The level of Blys in plasma with MM, stage Ⅰ~Ⅱ and stage Ⅲ~Ⅳ B-NHL are higer than those of healthy controls (P0.01); those before chemotherapy are higer than after chemotherapy in stage Ⅰ~Ⅱ and stage Ⅲ~Ⅳ B-NHL (P0.01), those in stage Ⅲ~Ⅳ are higer than in stage Ⅰ~Ⅱ before chemotherapy (P0.05). The diffuse large cell lymphoma (DLCL) is higher than small lymphocytic lymphoma (B-CLL/SLL) mantle cell lymphoma (MCL)(P0.01). Conclusions The level of Blys in plasma from patients with MM and B-NHL are significantly elevated, which correlate with histologic subtypes, different stage and therapy which suggests Blys might be involved in the pathogenesis of B cell malignancies, measurement of Blys might be a new item for the diagonosis, staging of B cell malignancies and evaluation of therapy." @default.
- W2365657974 created "2016-06-24" @default.
- W2365657974 creator A5044380069 @default.
- W2365657974 date "2007-01-01" @default.
- W2365657974 modified "2023-09-23" @default.
- W2365657974 title "Measurement and clinical significance of B lymphocyte stimulators level in peripheral blood plasma from patients with B cell malignancies" @default.
- W2365657974 hasPublicationYear "2007" @default.
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