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- W2365683997 abstract "Objective Gram-negative bacteria-induced multiple organ failure/dysfunction syndrome (MOF/MODS) is one of the leading causes of death through the world. The member of immunoglobulin family programmed death-1 ( PD-1) is a negative immune regulator. This study investigated the protective effect of PD-1 as well as the underlying mechanism in LPS-induced endotoxemia. Methods Ten PD-1 + / + and ten PD-1 knockout ( PD-1-/-) mice were injected peritoneally with LPS ( 10 mg /kg) ,and the survival was observed within 72 hrs after LPS injection. The other 40 PD-1 + / + and 40 PD-1-/- mice were injected peritoneally with LPS ( 5 mg /kg) . Blood samples were collected before injection and 1. 5,3 and 6 hrs after LPS injection ( n = 10 each time point) . Serum levels of various inflammatory mediators were measured using ELISA. Results The survival rate in PD-1-/- mice was noticeably lower than that in PD-1 + / + mice after 10 mg /kg LPS injection. Serum levels of inflammatory mediators TNF-α,IL-1β,IL-12 and IL-17 in PD-1-/- mice were higher than those in PD-1 + / + mice after 5 mg /kg LPS injection. Conclusions PD-1 can protect mice from LPS-induced endotoxemia probably through its regulation on inflammatory mediator production." @default.
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- W2365683997 date "2010-10-01" @default.
- W2365683997 modified "2023-09-22" @default.
- W2365683997 title "[Protection of PD-1 against LPS-induced endotoxemia and the underlying mechanism]." @default.
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