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- W2365687907 abstract "Objective:To investigate the association of a common functional polymorphism(Asp327Asn) in the sex hormone-binding globulin(SHBG)gene with type 2 diabetes mellitus(T2DM) in Chinese Han population.Methods:Asp327Asn polymorphism in 248 cases(T2DM group) and 351 controls(NC group) were genotyped by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technique.Homeostatic model assessment(HOMA) was used to assess beta cell function(HOMA-B) and insulin resistance(HOMA-IR).Results:The variant Asn allele frequency was significantly lower in T2DM group than(14.5%,20.1%,respectively) that in NC group.Unconditional logistic regression analysis showed that the variant Asn allele was associated with a reduced risk of T2DM(OR=0.62,95%CI:0.42~0.91,P=0.016).Conclusion:This study suggests that the Asn allele in the SHBG gene might be related to a reduced risk of T2DM in the Chinese Han population." @default.
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- W2365687907 date "2012-01-01" @default.
- W2365687907 modified "2023-09-24" @default.
- W2365687907 title "Association of Asp327Asn polymorphism in the sex hormone-binding globulin gene with type 2 diabetes mellitus in Chinese Han population" @default.
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