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- W2365702527 abstract "Objective:To investigate the relationship between the protein expression of matrix metalloproteinase-9(MMP-9) /tissue inhibitor of metalloproteinase-1(TIMP-1) in placenta and pregnancy-induced hypertension(PIH).Methods:In placenta from 20 cases of normal pregnancy and 48 cases of mild,moderate and severe group of pregnancies complicated with PIH,expression of MMP-9/TIMP-1 were mainly examined by immunohistochemistry.Results:MMP-9 and TIMP-1 were expressed in trophoblast or vassal wall of villous stroma or decidual tissue.In moderate and severe PIH,the expression of MMP-9and TIMP-1 were significantly lower than that in normal pregnancy and mild PIH(P0.01)respectively.But the differences of expression of MMP-9 mRNA in normal pregnancy and mild PIH were not significant(P0.05).In moderate and severe PIH,the number of villi and vessel(15.83±2.04) reduced and typical fibrinoid necrosis was observed.Conclusion:Abnormal expressions of MMP-9/TIMP-1 in placenta at maternal-fetal interface are related to the pathogenesis of PIH and typical pathological change in placenta." @default.
- W2365702527 created "2016-06-24" @default.
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- W2365702527 date "2005-01-01" @default.
- W2365702527 modified "2023-09-25" @default.
- W2365702527 title "Expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in placenta at maternal-fetal interface of patients with pregnancy induced hypertension" @default.
- W2365702527 hasPublicationYear "2005" @default.
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