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• W2365708562 startingPage "982" @default.
• W2365708562 abstract "Alternative RNA splicing represents a central mechanism for expanding the coding power of genomes. Individual RNA-binding proteins can control alternative splicing choices in hundreds of RNA transcripts, thereby tuning amounts and functions of large numbers of cellular proteins. We found that the RNA-binding protein SLM2 is essential for functional specification of glutamatergic synapses in the mouse hippocampus. Genome-wide mapping revealed a markedly selective SLM2-dependent splicing program primarily consisting of only a few target messenger RNAs that encode synaptic proteins. Genetic correction of a single SLM2-dependent target exon in the synaptic recognition molecule neurexin-1 was sufficient to rescue synaptic plasticity and behavioral defects in Slm2 knockout mice. These findings uncover a highly selective alternative splicing program that specifies synaptic properties in the central nervous system." @default.
• W2365708562 created "2016-06-24" @default.
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• W2365708562 date "2016-05-20" @default.
• W2365708562 modified "2023-09-29" @default.
• W2365708562 title "Control of neuronal synapse specification by a highly dedicated alternative splicing program" @default.
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• W2365708562 doi "https://doi.org/10.1126/science.aaf2397" @default.
• W2365708562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27174676" @default.
• W2365708562 hasPublicationYear "2016" @default.
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