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- W2365718003 abstract "OBJECTIVE To study the tissue distribution differences of chrysophanol loaded polybutylcyanoacrylate nanocapsules,chrysophanol-hydroxypropyl-β-cyclodextrin inclusion complex,chrysophanol liposomes in mice,through the tissue distribution of chrysophanol formulations to understand the pharmacodynamic properties of the formulations.With a view to electing for brain targeting the most strong,effect of chrysophanol best formulation.METHODS Mice tail intravenous injection of the equivalent dose of 10 mg·kg-1 chrysophanol formulations,by 0.25,1,2,4,8,12 h taking different points of mice heart,liver,spleen,lungs,kidneys,brain and blood plasma,after playing homogenized the protein processing using HPLC for the determination of chrysophanol in organizations of distribution.Chrysophanol was analyzed on a Thermo Hypersil ODS2 chromatographic column with mobile phase methanol-water(90∶10) at 1.0 mL·min-1flow rate and with column temperature 30 ℃.The wavelength of UV detector was set at 254 nm and injection volume was 20 μL.RESULTS Three kinds of chrysophanol formulations could prolong the elimination of time in vivo,and better targeting of tissues and organs than chrysophanol N,N-DMF solution.CONCLUSION Three kinds of chrysophanol formulations compared to tissue distribution,chrysophanol liposomes in various tissue distribution better,brain tissue targeting the most significant.Chrysophanol liposomes is expected to become the treatment of cerebrovascular disease clinical application of new dosage forms." @default.
- W2365718003 created "2016-06-24" @default.
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- W2365718003 date "2012-01-01" @default.
- W2365718003 modified "2023-10-15" @default.
- W2365718003 title "Tissue Distribution of Three Chrysophanol Formulations in Mice" @default.
- W2365718003 hasPublicationYear "2012" @default.
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