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- W2365725065 abstract "Objective To explore the effects of quetiapine and clozapine on social function and quality of life in patients with schizophrenia .Methods A total of 164 patients with schizophenia were randomly divided into quetiapine group and clozapine group for 12-week of treament.PANSS was used to assess negative symptoms,positive symptoms and pathology symptoms,Generic Quality of Life Inventory (GQOLI) to assess quatity of life,and Social Disability Screening Schedule (SDSS) to assess social function,Results After 12-week treatment ,total scores and factor scores of PANSS in two groups signifcanty decreased,there was no significant difference between two groups.In clozapine group,total score of GQOLI,factor scores of physical uncomfortable feeling,appetite and sex function,sports and feeling,cognitine function,marriage and family significantly decreased after treatment.While in quetiapine group,scores of dimensions in physical health,psychological health,marriage and family significantly increased after treatment.There had significanty differnces on total scores of GQOLI,dimensions of physical health,psychological health and social function,item factors of family ,interesting,concern of future,responsibility and plan between two groups.Conclusion Quetiapine has better effects for improving social function and quality of life in patients with schizophrenia." @default.
- W2365725065 created "2016-06-24" @default.
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- W2365725065 date "2009-01-01" @default.
- W2365725065 modified "2023-09-24" @default.
- W2365725065 title "Effects of quetiapine and clozapine on social function and quality of life in patients with schizophrenia" @default.
- W2365725065 hasPublicationYear "2009" @default.
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