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- W2365739174 abstract "Objective To investigate the effects of probucol on high fat-high cholesterol(HFHC)diet-induced hyperlipidemia,and the activity and expression of C-reactive protein(CRP)in apo E knockout mice and genetic background C57BL/6J mice.Methods The mice models were build by fed HFHC-diet(15%lard and 0.25%cholesterol).The serum levels of lipids and the activity of CRP were determined by commercially provided kits.The liver slices were stained by hematoxylin eosin(HE)staining.The CRP mRNA expression levels in liver were demonstrated by reverse transcription-polymerase chain reaction(RT-PCR).Results At the end of 12 weeks,the levels of serum lipid were increased in HFHC groups compared with the control group(P0.05),and decreased by probucol in hyperlipidemic mice.Probucol contributed to a significant decrease of lipid content of the liver tissue in mice by HE staining.Furthermore,compared with respective control groups,the serum levels of CRP were increased in HFHC-treatment mice(P0.05).The administration of probucol decreased the serum levels of CRP and suppressed the CRP expression in liver compared with HFHC groups(P0.05).Conclusion Probucol decreases the levels of serum lipids in HFHC diet-induced hyperlipidemic mice,and downregulates the CRP expressions in the livers of the HFHC diet-induced hyperlipidemic mice.This may be show the therapeutic effects of probucol by anti-inflammatory." @default.
- W2365739174 created "2016-06-24" @default.
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- W2365739174 date "2008-01-01" @default.
- W2365739174 modified "2023-09-27" @default.
- W2365739174 title "Effects of probucol on the expression of C-reactive protein in Hyperlipidemic Mice" @default.
- W2365739174 hasPublicationYear "2008" @default.
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