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- W2365741632 abstract "To prepare salicylic acid and chloramphenicol pullulan plaster(SACPP)and investigate chloramphenicol release using HPLC method in vitro and in vivo.The permeation rate and penetration mechanism of SACPP through rat skin in vitro were examined using the standing posture Franzs type diffusion cell.The permeation tests demonstrated that the optimized chloramphenicol controlled-release plaster exhibited Higuchi model.The chloramphenicol plasma concentration was determined and the pharmacokinetics of chloramphenicol was studied after using plaster in rabbits.The chloramphenicol plasma concentration reached a peak(ρmax,1.24μg/mL)after 1h.The areas under plasma concentration curves(AUC)of chloramphenicol using plaster with ultrasonic was better than that without ultrasonic.Chloramphenicol in SACPP was delayed release.It was evident that the SACPP with ultrasonic exhibited good transdermal delivery properties.There was a high correlation between in vitro transdermal delivery and in vivo percutaneous absorption using SACPP,and the chloramphenicol release in vitro could predict its absorption in vivo." @default.
- W2365741632 created "2016-06-24" @default.
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- W2365741632 date "2013-01-01" @default.
- W2365741632 modified "2023-09-23" @default.
- W2365741632 title "Chloramphenicol release evaluation of salicylic acid and chloramphenicol plaster in vitro and in vivo" @default.
- W2365741632 hasPublicationYear "2013" @default.
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