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- W2365745802 abstract "Objective To investigate the changes and relations of serum IL-10 levels of myocardium myeloperoxidase (MPO) during acute myocardial ischemia and reperfusion in rats in order to supply experiment basis for clinical diagnosis. Methods 63 rats were divided into three groups at random, including 21 control rats, 21 model rats who received i.v. bolus placebo and 21 administration rats who received i.v. bolus methylprednisolone before ischemia. Among them model and administration groups subjected to myocardial ischemia and reperfusion. Plasma IL-10 by ELISA was measured at 0.5 hour after ischemia and 0.5, 2 hours after reperfusion, meantime myocardial myeloperoxidase (MPO) were measured at respective time points. Results IL-10 change little in control group. Significant levels of IL-10 were showed in both model and administration groups from ischemia 0.5 hour to 0.5 hour, 2 hours after myocardial reperfusion(model group:F=26.075,P0.01; administration group: F=39.263,P0.01). Levels of IL-10 increased significantly from control group to model group, administration group at same time point(ischemia 0.5 h: F= 85.383, P0.05; I/R 0.5 h: F=64.923, P0.01; I/R 2h: F=131.727, P0.01) .MPO significantly rose following prolonging reperfusion time (MPO: model group:F=4.153, P0.05; administration group: F=8.725, P0.01), but declined slightly with more reperfusion extending. Concentrations of MPO in administration group were lower than those in model group at respective time point(P0.05). The expression of IL-10 neglect correlated with MPO after reperfusion(P0.05). Conclusions The present findings indicated that mythylprednisolone enhanced highly release of endogenous IL-10. Level of IL-10 showed indirectly scale of inflammation during the ischemia and reperfued myocardia." @default.
- W2365745802 created "2016-06-24" @default.
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- W2365745802 date "2004-01-01" @default.
- W2365745802 modified "2023-09-23" @default.
- W2365745802 title "Change and significance of endogenous Interleukin-10 during myocardial ischemia and reperfusion in rats" @default.
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