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- W2365753465 abstract "Objective:To investigate the apoptosis-inducing effect of TRAIL and Ara-C on acute myeloid leukemic(AML) cells. Methods:Thirty-nine cases of BMMNC of AML cells were isolated. All cases were divided into 4 groups, which were control group, TRAIL group, Ara-C group and TRAIL+ Ara-C group.MTT assays were used to evaluate the cytotoxic effect at 12, 24 and 48 hours after the drugs were added. Flow cytometry was used to evaluate apoptosis. Results:TRAIL and Ara-C can synergistically inactivate AML cells, and induce apoptosis. This kind of effect presented a dose-and time-dependent relationship.Conclusion:TRAIL can present a synergistic effect with Ara-C.The cytotoxic effect was mostly induced by apoptosis. TRAIL has a promising prospect in clinical use." @default.
- W2365753465 created "2016-06-24" @default.
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- W2365753465 date "2004-01-01" @default.
- W2365753465 modified "2023-09-25" @default.
- W2365753465 title "An experimental research of apoptosis-inducing effect of TRAIL and Ara-C on acute myeloid leukemic cells" @default.
- W2365753465 hasPublicationYear "2004" @default.
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