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- W2365756064 abstract "OBJECTIVE The stability of insulin in the gastrointestinal (GI) tract was investigated. METHODS The concentration of insulin solution was chosen according to the circular dichroism spectra. Insulin was incubated with solutions which had the different pH or contained all kinds of proteolytic enzymes and then the contents and bioactivities of insulin were determined by HPLC and mice hypoglycemia, respectively. RESULTS Insulin was monomer when the concentration of insulin solution was chosen to be 100μg·mL-1 .The contents and bioactivities of insulin solution were unchanged within 3 h in the acidic and neutral environment. Insulin was degraded when incubated with all kinds of proteolytic enzymes and the contents and bioactivities were reduced with the increase of the incubation time. CONCLUSION Various proteolytic enzymes in the GI tract is the predominant barrier which the oral insulin delivery system need to overcome.Therefore,several formulation strategies should be applied in order to enhance the stability of insulin and increase the absorption." @default.
- W2365756064 created "2016-06-24" @default.
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- W2365756064 date "2004-01-01" @default.
- W2365756064 modified "2023-09-23" @default.
- W2365756064 title "Study on the stability of oral insulin in gastrointestinal tract" @default.
- W2365756064 hasPublicationYear "2004" @default.
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