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- W2365756665 abstract "Objective To investigate the relationship between 12 candidate genes responsible for regulating water, sodium metabolism and membrane ion transport and essential hypertension (EH) in Chinese. Methods Linkage analysis was performed in 95 Chinese nuclear families including 477 subjects using a technique of fluorescence-based gene scan with microsatellite markers. Markers were selected on the chromosomal regions containing candidate genes responsible for regulation of water, sodium metabolism and ion transport. The two-point, non-parametric linkage analysis (NPL), maximum LOD score analysis and transmission /disequilibrium test(TDT)were used by Genehunter software package in this study. Results The NPL analysis and TDT indicated a positive linkage at D12S398 (z=2.08,P0.05 and χ2=9.00, P0.005,respectively). LOD score analysis supported significant linkage at D12S398 with a small P value (LOD score=1.26, P0.01). No significant linkages were found at other loci(P0.05). Conclusion D12S398, a marker near vasopress in receptor 1A gene (V1AR), shows positive linkage with EH by using three statistical methods (NPL, LOD Score, and TDT). This region deserves to be further explored." @default.
- W2365756665 created "2016-06-24" @default.
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- W2365756665 date "2001-01-01" @default.
- W2365756665 modified "2023-09-24" @default.
- W2365756665 title "Linkage analysis of 12 candidate gene loci regulating water, sodium metabolism and membrane ion transport in essential hypertension" @default.
- W2365756665 hasPublicationYear "2001" @default.
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