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• W2365760166 abstract "Objective To compare the hemodynamic response to rapid plasma volume expansion with crystalloid and colloid during induction of general anesthesia. Methods Sixty ASA Ⅰ - Ⅱ patients of both sexes (36 male, 24 female) aged 22-65 yr undergoing elective major abdominal surgery were randomly allocated to one of 3 groups (A, B, C) 20 in each group receiving either crystalloid or colloid. The patients were unpremedicated The patients were sedated with intravenous midazolam 0.04 mg·kg-1' . Radial artery and right internal jugular vein were cannulated under local infiltration for BP and CVP monitoring. ECG, SpO2 and PET CO2 were continuously monitored during anesthesia. Cardiac function was monitored by impedance cardiogaphy. Anesthesia was induced with fentanyl 3 μg·kg-1 , propofol 1.6 mg·kg-1 in divided doses and vecuronium 0.1 mg·kg-1 . After tracheal intubation the patients were mechanically ventilated and PETCO2 was maintained at 35-40 mm Hg. Anesthesia was maintained with isoflurane and intermittent i.v. doses of fentanyl and vecuronium. In group A lactated Ringer's solution (RL) was infused at 15 ml · kg-1· h-1 as soon as induction of anesthesia was started. In group B and C RL (B) or 6% hydroxyethyl starch (HES) (C) 7 ml·kg-1 was infused in 20 min before induction of anesthesia. As soon as induction was started another 13 ml·kg-1 of RL or HES was infused in 20 min. Results (1) The SBP was significantly lower in group A than in group B and C and the HR was not significantly different among the 3 groups. (2) The CVP gradually increased with fluid infusion. The degree of increase was in the order of CBA ( P 0 05) (3) The cardiac index (CI) began to decrease after induction and was still lower than the baseline after intubation in group A while in group B and C CI increased slightly after induction and then gradually decreased to the level lower than the baseline in group B, but was maintained at baseline level in group C. (4) The systemic vascular resistance (SVR) slightly increased or was unchanged in group A and B but was significantly decreased in group C after induction and intubation. (5) The acceleration index (ACI) slightly decreased after induction and intubation in group A whereas in group B significantly increased after induction then gradually returned to the baseline level after intubation, but in group C ACI significantly increased after induction and intubation. Conclusion The effect of rapid plasma volume expansion with crystalloid or colloid on prevention of hypotension during induction is similar but colloid is better in prevention of CI decrease." @default.
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• W2365760166 date "2005-01-01" @default.
• W2365760166 modified "2023-09-25" @default.
• W2365760166 title "Hemodynamic response to rapid plasma volume expansion in patients scheduled for abdominal surgery during induction of general anesthesia" @default.
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