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- W2365762955 abstract "【Objective】To explore the effect of low-frequence pulse ultrasound(US)on human hepatoma MDR cells and mechanism.【Methods】HepG2/ADM cells were cultured in vitro and randomly divided into 4 groups:control group(HepG2/ADM only),group ADM(adding 0.5ug/ml adriamycin for 1 h),group US (low-frequence pulse ultrasound for 10 min),and group US combinated with adriamycin simultaneously.A pulsed US sonication at a frequency of 800 KHz was delivered with an intensity level of 3.0 W/cm2.The apoptosis of HepG2/ADM was evaluated by fluorescence microscopy,DNA fragmentation assay and flow cytometry assay.【Results】HepG2/ADM cells radiated by US had the typical characteristics of apoptosis.Comparaed with the control group(HepG2/ADM),the apoptosis rates were higher in ADM or/and US group.The therapeutic alliance of US and ADM for MDR cells,have a significant change in the ratio of apoptosis(30.1%).【Conclusions】The US sonication of 800KHz could induce apoptosis of HpG2/ADM cell in vitro,and could act synergistically with adriamycin." @default.
- W2365762955 created "2016-06-24" @default.
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- W2365762955 date "2007-01-01" @default.
- W2365762955 modified "2023-09-27" @default.
- W2365762955 title "Experimental study on the apoptosis of human liver carcinoma MDR cells induced by low-frequence pulse ultrasound exposure" @default.
- W2365762955 hasPublicationYear "2007" @default.
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