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- W2365780753 abstract "Objective To observe the effect of acupuncture on apoptosis and Caspase-9 expression in hippocampus of cerebral ischemia (CI) rats. Methods Thirty male SD rats were randomized into control, CI and CI + acupuncture group, with 10 cases in each group. CI model was established by occlusion of the unilateral middle cerebral artery. Baihui (GV20) and Shuigou (GV26) were acupunctured once daily for 7 days. The apoptosis and expression of protein Caspase-9 in hippocampus was displayed by HE staining and immunohistochemical method. Results In comparison with the normal control group, Caspase-9 immune reaction (IR) positive cells in the hippocampus of CI group increased significantly (P 0.01). Caspase-9 IR positive ceUs in the hippocampus of CI + acupuncture group decreased significantly (P0.01). HE staining showed that there was a lot of neuron degenerateion and necrosis in the ischemia focus, and the manifestations of cerebral edema were observed. Degeneration and necrosis of cells was significantly decreased after acupuncture. Conclusion Acupuncture can eliminate cerebral ischemia induced abnormal expression of Caspase-9 and alleviate cerebral lesion in cerebral ischemia rats. These may be one of the mechanisms of acupuncture lightening the cerebral ischemia." @default.
- W2365780753 created "2016-06-24" @default.
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- W2365780753 date "2009-01-01" @default.
- W2365780753 modified "2023-09-25" @default.
- W2365780753 title "Effect of Acupuncture on Apoptosis and Protein Caspase-9 Expression in Hippocampus of Cerebral Ischemia Rats" @default.
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