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- W2365781683 abstract "Objective To study the HLA-DRB1,DQB1 allele polymorphism and genetic characters in Kunming Han population.Methods HLA-DRB1,DQB1 DNA typings in the 72 Kunming Han nationality children were analyzed by polymerase chain reaction with sequence specific primer(PCRSSP).Results Total 72 specificities were detected in HLA-DRB1,DQB1 and 12 alleles in HLA-DRB1 locus,7alleles in HLA-DQB1 locus were observed in 72 children of Kunming Hans.The more frequently observed alleles were HLA-DRB1*12(20.14%),DRB1*0901(19.44%),DRB1*04(18.06%)in HLA-DRB1 locus in turn.The other common alleles(10%) were HLA-DRB1*08(11.11%),DRB1*15(10.42%) in turn.The more frequently observed alleles were HLA-DQB1*0301(27.08%)、DQB1*06(21.53%) in HLA-DQB1 locus in turn..The other common alleles(10%) were HLA-DQB1*0303(15.97%),DQB1*05(13.19%).Meanwhile,comparison of HLA-DRB1,DQB1 allele polymorphism of Kunming Han nationality population with the North and the South Han nationality populations,showed some significant differences(P0.001).Conclusions The distribution of HLA-DRB1,DQB1 allele polymorphism in the Kunming Han population likes neither to the South Han population nor to the North Han population.It is unique in the distribution of HLA allele.The complicated migratory history of Kunming Han population、the unique topography of Kunming and the mergence among nationalities may be its reasons." @default.
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- W2365781683 date "2006-01-01" @default.
- W2365781683 modified "2023-09-23" @default.
- W2365781683 title "Characterization and Distribution of HLA-DRB1,DQB1 Allele Polymorphism in the Kunming Han Population" @default.
- W2365781683 hasPublicationYear "2006" @default.
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