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• W2365782022 abstract "Objective To explore the efficacy and adverse effects of different dose of capecitabine in the maintenance treatment for patients with advanced nasopharyngeal carcinoma. Methods One hundred and twenty patients with advanced nasopharyngeal carcinoma were randomized into three groups evenly. In control group, patients were given Taxol 135 mg/m2 plus Cisplatin 80 mg/m2d1, which were repeated every three weeks and totally for four cycles. In high dose maintanance group, patients were given Taxol 135 mg/m2 plus Cisplatin 80 mg/m2d1, which were repeated every three weeks and totally for four cycles, then Capecitabine maintenance treatment was carried out with1 000 mg/m2 bid for 14 days. In low dose maintance group, patients were given Taxol 135 mg/m2d1 plus Cisplatin80 mg/m2d1, which were repeated every three weeks and totally for four cycles and Capecitabine maintenance treatment was then carried out with 1 000 mg/m2 qd for 14 days. Results All 120 patients involved had evaluable lesions.The PR+CR rates of control group, high dose maintance group and low dose maintance group were 45.0%(18/40),50%(20/40) and 47.5%(19/40) respectively. The ratios of TTP of those three groups were(5.650 ± 0.207) months,(8.900 ± 0.849) months and(8.400 ± 1.684) months respectively, and the ratios of MST were(11.3 ± 0.434) months,(17.8±1.641) months, and(16.9±3.422) months respectively. One-year survival rates of the three groups were 27.5%(11/40), 70.0%(28/40) and 52.5%(21/40) respectively. There were no significant differences among the three groups in PR+CR rate(P0.05), while there were significant differences among the three groups in one-year survival rate,TTP and MST(P0.05). For the toxicity, there was significant difference between high dose maintanance group and low dose maintanance group in gastrointestinal reaction, while there were no significant differences in hematological toxicity or hand-foot syndrome(P0.05). Conclusion For patients with advanced nasopharyngeal carcinoma, the efficacy of Capecitabine maintenance treatment is good. The gastrointestinal toxicity of low dose group is milder than that of high dose one. Low dose Capecitabine maintenance treatment is convenient for long-term use." @default.
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• W2365782022 date "2014-01-01" @default.
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• W2365782022 title "Clinical study on different dose of capecitabine in the maintenance treatment for patients with advanced nasopharyngeal carcinoma" @default.
• W2365782022 hasPublicationYear "2014" @default.
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