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- W2365783368 abstract "Objective Using the Descemet's membrane-removed rhesus autologous corneal as the cell carrier and transplant the cultured human umbilical vein endothelial cells( HUVEC) to the inner surface of the cornea,to observe the function of HUVEC after alternative rhesus monkey corneal endothelial cell and the growth of the HUVEC in the rhesus monkey eye corneal surface.Methods The experimented monkeys were divided into 3 groups: experimental group( 3 cases),experimental control group( 2 cases) and blank control group( 1 case). In experimental group,cultured HUVEC were transplanted onto rhesus monkey posterior corneal surface without corneal endothelium; In experimental control group,the detached corneal Descemet membrane of rhesus monkey fixed in suit without cultured HUVEC transplantation; In blank control group,a simple penetrativity corneal transplantation without destroy the descemet membrane performed. The transparent of implants in each group was observed after corneal transplantation. Histopathology of cornea grafts,immunohistochemistry and scanning electron microscope were performed at 30 days and 60 days postoperatively in order to observe the appearance of HUVEC onto the monkey posterior corneal surface and the structure of anterior chamber angle. Results The corneal implants of experimental group kept transparency and thickness in some extent while the experimental control group showed severity corneal edema and bullae. Histopathology of corneal grafts showed that a cells layer with CD34 staining positive reaction growth on posterior corneal surface of corneal button in the experimental group,which indicated that the layer of cells were HUVEC,no cell and material like membrane could be seen on that of the experimental control group; A layer of corneal endothelial cells and Descemet's membrane were visible on that of the blank control group.Scanning electron microscope showed that a layer of HUVEC were growing on the posterior surface of cornea button with plenty of leucocytes and small amounts of cell debris could be found to block up the trabecula meshwork,collagen fibers remained on the posterior surface of cornea button of the experimental control group with no cell grown; The complete corneal endothelial cells layer with six-fringe shape could be found in the blank control group. Conclusion HUVEC can survive and enduce the barrier function at the posterior surface of rhesus monkey cornea without corneal endothelial cells,and keep the cornea button transparency and normal thickness in some extent,but severe rejection will happen." @default.
- W2365783368 created "2016-06-24" @default.
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- W2365783368 date "2014-01-01" @default.
- W2365783368 modified "2023-09-28" @default.
- W2365783368 title "Microstructure observation of human vascular endothelial cells transplantation in autograft to replace monkey corneal endothelial cells" @default.
- W2365783368 hasPublicationYear "2014" @default.
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