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- W2365783608 abstract "Objective To investigate the effects of sirolimus or catopril and their combination on allograft angiopathy in rats.Methods The establishment of allograft model was achieved by carotid transplantation in rats.60 rats were randomly classified into four groups according to being given different medicine: the controlled group(A),catopril-treated group(B),sirolimus-treated group(C) and combination-treated group(D).At 0,8 weeks after transplantation the NO content in blood serum were measured and the grafts were harvested for observing the regional changes in the intimal layers by light microscopy and the expression of TGF-β1,VCAM-1,PCNA% and CD4+T cells count in the allograft by immunohistochemistry.Results There was a reduced intimal thickness in both catopril-treated group and sirolimus-treated group,especially in the combined treated group.The number of CD4+T cell infiltration in allograft of group B,group C and group D was less than that of group A(P0.05).The NO content in serum of group B and group D was higher than that of group A(P0.05).There was weak expression of TGF-β1,VCAM-1 in allograft and lower PCNA(%) in group B,group C and group D than those in group A(P0.05).Conclusion The prevention of catopril and sirolimus on allograft angiopathy is significant and the effect was most obvious when drugs were used combinedly." @default.
- W2365783608 created "2016-06-24" @default.
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- W2365783608 date "2008-01-01" @default.
- W2365783608 modified "2023-09-25" @default.
- W2365783608 title "Research on the Effects of Sirolimus Associated with Catopril on Allograft Angiopathy in Rats" @default.
- W2365783608 hasPublicationYear "2008" @default.
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