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- W2365783958 abstract "Objective To investigate the death pattern of pheochromocyoma cell line (PC12 cell) irradiated with ionizing radiation and to search for a model of radiation-induced neuron injury in vitro. Methods PC12 cell was irradiated with different doses of ~ 60 Co γ-rays. The effect of radiation on cell cycle, development, differentiation and death rate were detected by flow cytometry, light microscope, and transmission electron microscope (TEM). Results Irradiated PC12 cell showed cell cycle retardation and differentiation, but some cells died due to swelling. Apoptosis was observed in few cells. TEM examination indicated that mitochondrion and endoplasmic reticulum were dilated markedly, chromatin was concentrated and scattered near karyotheca or around the nucleolus, which characterized oncosis. Conclusions PC12 cell died through oncosis after gamma-ray irradiation of high-dose, and can be used as a radiation-induced neuron injury model.;" @default.
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- W2365783958 date "2006-10-25" @default.
- W2365783958 modified "2023-09-25" @default.
- W2365783958 title "Preliminary research on death pattern in PC12 cell after high-dose of gamma-ray irradiation" @default.
- W2365783958 doi "https://doi.org/10.3760/cma.j.issn.0254-5098.2006.05.007" @default.
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