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- W2365790783 abstract "Four kinds of McAbs (anti CD4, CD8, CD19 and CD57) were used to separate CD4, CD8, CD19 (B) and CD57 (NK) lymphocyte subsets from human peripheral blood by Panning-direct method. First the natural killing activity of each subsets and the regulatory functions between CD57 and other subsets were studied. Then the effects of low dose radiation on the function of CD57 cells and the regulatory functions between CD57 and other subsets were studied. The results showed that the NK activity was found in all of the four subsets, with CD57 cell having the strongest activity. When CD4 and CD57 cells were co-cultured, the total NK activity was higher than that of the sum of these two single subsets, i. e. there was synergistic effect between CD4 and CD57 cells. When CD8 or CD19 cells were co-cultured separately with CD57 cells, no synergistic effect was found. Irradiation by gamma rays at doses of 50 cGy and 80 cGy was able to stimulate the function of CD57 cells. After CD4 or CD57 cells were irradiated, the total NK activity of their co-culture increased significantly. This phenomenon was not found in other subsets. This suggested that low dose radiation can enhance the synergistic action between CD4 and CD57 cells. So at least four subsets (CD4, CD8, CD19, CD57) contribute to the total NK activity of peripheral blood mononuclear cells." @default.
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- W2365790783 date "1997-01-01" @default.
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- W2365790783 title "EFFECTS OF LOW DOSE RADIATION ON REGULATORY FUNCTION BETWEEN LYMPHOCYTE SUBSETS" @default.
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