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- W2365794604 abstract "Objective: To explore the absorption percentage of faropenem in various segments of rat's intestines to find out the most effective absorption location and provide scientific basis for the preparation of a rational dosage form. Methods: The intestine in rats was cannulated for in situ circumfluence, the intestinal segments was subdivided as the following standard: the duodenum segment (start at the intestinal segment 1cm distance from pylorus), the jejunum segment (start at the intestinal segment 15cm distance to pylorus), the ileum segment (start at the intestinal segment 20cm distance to cecum), and colon segment (start at the subjacent cecum). The absorption of faropenem after 2 hours circumfluence was determinated through gradient elution method by HPLC. Results: Average absorption percentages of faropenem at duodenum, jejunum, ileum, and colon were 6.91±3.08 %, 5.66±2.29 %, 9.62±4.08 %, and 4.65±1.29 % respectively. The RSD of stability tests, precision tests and recovery tests were 0.48 %, 0.234 %, and 2.01% respectively. Conclusions: The sequence of faropenem absorption percentages of intestinal segments from high to low is located at ileum, duodenum, jejunum, and colon. Ileum is the most effective absorption location for faropenem." @default.
- W2365794604 created "2016-06-24" @default.
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- W2365794604 date "2009-01-01" @default.
- W2365794604 modified "2023-09-25" @default.
- W2365794604 title "Preliminary Studies on the Absorption Location of Faropenem in Rat's Intestines" @default.
- W2365794604 hasPublicationYear "2009" @default.
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