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- W2365796422 abstract "Objective To study the apoptosis and expressions of Caspase-8 and Fas/FasL in hemangioma endothelial cells.Methods Forty-four hemangioma specimens were classified by Mulliken′s classification and the expression of proliferating cell nuclear antigen(PCNA).The expression of PCNA,Fas,FasL and Caspase-8 were detected by immunohistochemistry Evision method.SPSS 13.0 software was used to analyze the data.Results Hemangioma was classified as 25 cases of proliferating phase hemangioma and 19 involuting phase hemangioma.In the proliferating phase hemangioma,the integral absorbance(IA) of Caspase-8,Fas and FasL were 1 186.42±863.86,99.08±54.80,538.65±344.41,respectively.In the involuting phase hemangioma,the IA of Caspase-8,Fas and FasL were 20 544.18±7 556.04,714.34±288.38,1 917.12±507.21,respectively.In the hemangioma involuting phase specimens,the IA of Fas,FasL and Caspase-8 were obviously higher than those in proliferating phase specimens(Pa0.01).Meanwhile,Fas and Caspase-8 had positive correlation(r=0.644 P0.01).Conclusions Caspase-8 and Fas/FasL might play an important role in the hemangioma endothelial cell apoptosis.The apoptosis of hemangioma endothelial cells may be mediated by the Fas/FasL pathway." @default.
- W2365796422 created "2016-06-24" @default.
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- W2365796422 date "2009-01-01" @default.
- W2365796422 modified "2023-09-24" @default.
- W2365796422 title "Expressions of Caspase-8 and Fas/FasL in Children with Hemangioma" @default.
- W2365796422 hasPublicationYear "2009" @default.
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