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- W2365811279 abstract "Pharmacokinetics of orbifloxacin in rabbits was studied by reversed-phase high performance liquid chromatography.After intramuscular administration at the does of 10 mg per kg body weight,blood samples were collected at different intervals and orbifloxacin concentrations were measured by high performance liquid chromatography.All of those dates were treated by MCPKP pharmacokinetic software.The results showed that the concentration-time curve of orbifloxacin in plasma was fitted to a two-compartment open model with first order absorption,he absorption half-life T1/2Ka was 0.266 9 h ;elimination half-life T1/2β was 7.154 6 h,Tmax is 0.563 h,Cmax was 4.871 73 μg/mL,AUC was 18.453 5 mg/L·ht.Pharmacokinetic characteristic of orbifloxacin in the rabbits is:absorbs rapidly,distributes quickly,eliminates slowly,reaches the peak time to be short,the peak density is high,medicine under the curve the area is big." @default.
- W2365811279 created "2016-06-24" @default.
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- W2365811279 date "2009-01-01" @default.
- W2365811279 modified "2023-09-27" @default.
- W2365811279 title "Pharmacokinetic studies of orbifloxacin in rabbits" @default.
- W2365811279 hasPublicationYear "2009" @default.
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