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- W2365834204 abstract "AIM To study the effects of U50488H on the contents of NO, ET and Ang Ⅱ in HPH rats and to explore the mechanisms underlying the preventive and therapeutic effects of U50488H on hypoxic pulmonary hypertension (HPH). METHODS Thirty-two rats randomly received one of the following treatments: normoxia control, 2w hypoxia, 2w hypoxia + normal saline and 2w hypoxia+U50488H. The rats were exposed to low-pressure and low-oxygen condition in an auto-modulating hypobaric and hypoxic cabin (air pressure 50 kPa) to establish HPH animal model. After 2 weeks of chronic hypoxia, concentrations of NO, ET and Ang Ⅱ in blood and the contents in lung tissues were detected by nitrate reductase assay or radio immunoassay. RESULTS After 2 weeks of chronic hypoxia, NO level decreased while ET and Ang Ⅱ levels increased remarkably in both blood and lung tissues(P0.01). In 2w hypoxia + U50488H group, the concentration of NO was higher and the concentration of ET and Ang Ⅱ were lower than those of 2w hypoxia group(P0.01). CONCLUSION U50488H significantly increases NO content and decreases ET and Ang Ⅱ contents in both blood and pulmonary tissues of HPH rats. It may be one of the mechanisms underlying the preventive and therapeutic effect of U50488H on HPH." @default.
- W2365834204 created "2016-06-24" @default.
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- W2365834204 date "2007-01-01" @default.
- W2365834204 modified "2023-09-25" @default.
- W2365834204 title "Effects of U50488H on contents of NO,ET and Ang II in hypoxic pulmonary hypertension rats" @default.
- W2365834204 hasPublicationYear "2007" @default.
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