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- W2365851845 abstract "Objective To explore the effects of SHU AN Injection (SAI) on experimental intracerebral hemorrhage (ICH) and the expressions of nerve growth factor (NGF) and interneukin-1β (IL-1β) after ICH injury in rat.Methods Model of capsuloganglionic hemorrhage in rats was made through injection of 120 μl auto-femoral arterial blood, and the rats with ICH were treated with SAI and nimodipine injection for 7 days. Northern blot and enzyme linked immunosorbent assay (ELISA) were employed to detect the mRNA and proteins of NGF and IL-1β in rat brain tissues.Results After the SAI treatment, the neurologic grades and the concentrate of water and Na + in cerebral tissue were lower significantly compared with control group. The expressions of NGF and IL-1β mRNA increased on the first day after ICH injury, decreased to the normal level on the second day and decreased to the level under normal on the 4th and 7th . Both NGF protein and IL-1β protein contents increased markedly from 1 day after hemorrhage, still higher than normal 7 days later. The changes of NGF mRNA and protein content of SAI group were same as model group, but the IL-1β mRNA and protein in SAI group were significantly lower than those in model group at all time points. Conclusions SAI could promote the neural function recovery following ICH in rats significantly, and its mechanism probably was related to repress IL-1βmRNA expression and upregulate the expression of NCF." @default.
- W2365851845 created "2016-06-24" @default.
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- W2365851845 date "2004-01-01" @default.
- W2365851845 modified "2023-09-25" @default.
- W2365851845 title "Effects of SHU AN Injection on regulating expressions of NGF and IL-1β following intracerebral hemorrhage in rats" @default.
- W2365851845 hasPublicationYear "2004" @default.
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