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- W2365852072 abstract "Objective:Comparative study on the differences of male reproductive toxicity disturbed by Tripterygium Wilfordii Multiglycoside(GTW) in normal rats and adjuvant induced arthritic rats(AA rat).Methods:male SD rats were randomly divided into two groups,normal group and AA group.GTW 0,7,70 and 105 mg.kg-1 day-1 was given to rats intragastrically for two weeks.After that,all animals were sacrificed,the testicle and epididymal coefficient were calculated,histopathological changes of testis was observed by HE and NOS antibody immunohistochemical procedure,and the NOS level in testicle tissue was tested by chemical colorimetric method.Results:The changes were not detected both in normal group and AA group treated by 7mg.kg-1 GTW(clinical equal effective dosage).70 mg.kg-1 GTW can induce testis toxicity in normal rats.However,none adverse impacts were observed in AA rats.105 mg.kg-1 GTW can arouse significant testis toxicity both in normal rats and AA rats.Conclusion:There is the dose-related feature on testis toxicity of GTW.On the other side,the testis toxicity is relative to physiological status.The same dosage GTW can rouse weak testis toxicity in AA rats than that in normal rats." @default.
- W2365852072 created "2016-06-24" @default.
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- W2365852072 date "2011-01-01" @default.
- W2365852072 modified "2023-09-23" @default.
- W2365852072 title "Comparative study on effect of poly glycosides of Tripterygium wilfordii Hook on morphology of testicles and expression of NOS in normal and adjuvant-induced arthritis rats" @default.
- W2365852072 hasPublicationYear "2011" @default.
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