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- W2365853475 abstract "Objective To investigate the influence of all-trans retinoic acid(ATRA)on the mecha- nisms of transconformation,immigration and multiplication signal conduction of vascular smooth muscle cell in carotid atherosclerosis in rabbits.Methods Rabbits were randomly divided into three groups:normal group(n=12),control group(n=12)and ATRA treated group(n=12).All the three groups were fed by high-cholesterol diet and control group was made into carotid atherosclerosis model using air-drying after two weeks.The ATRA treated group was fed by all-trans retinoic acid.On the 14d and 28d,the target vessel was taken out,MAPK and C-fos were observed by immunostaining.The carotid arteries were harvested sev- eral weeks after the operation.Results proliferation degree and expression level of MAPK and C-fos in en- domembrane of treated group is respectively lower(P＜0.05)and higher(P＜0.05)than operated group, which is observed morphologically.Conclusion Our results indicate that ATRA treatment can inhibit ather- oaclerotic progression by inhibiting the proliferation of vascular smooth muscle cells.The mechanism may be related to inhibition of the expression of MAPK and C-fos in vascular smooth muscle cells." @default.
- W2365853475 created "2016-06-24" @default.
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- W2365853475 date "2007-01-01" @default.
- W2365853475 modified "2023-09-24" @default.
- W2365853475 title "Effects of All-trans Retinoic Acid(ATRA)on the Proliferation Signal Conduction Pathway of VSMC in Atherosclerotic Focus of Infection in Rabbits Carotid Artery" @default.
- W2365853475 hasPublicationYear "2007" @default.
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