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- W2365853859 abstract "AIM To compare the effect of phospholipid composition on pharmaceutical characteristics and acute toxicity of liposomes containing zedoary turmeric oil(ZTO) and ZTO hydroxypropyl-β-cyclodextrin inclusion complex(ZTO-CD).METHODS ZTO-CD was prepared by saturated water solution method and obtained by freeze-drying technique.The liposomes were prepared by ethanol injection method and used to encapsulate ZTO-CD into liposomes.Pharmaceutical characteristics such as entrapment efficiency,size,zeta potential,release profiles and stability were determined and compared between ZTO-CD-loaded liposomes with different phospholipid composition(SPC or HSPC+SPC).Acute toxicity of ZTO solution,ZTO-CD and ZTO-CD-loaded liposomes with different phospholipid composition was also compared.RESULTS ZTO-CD-loaded HSPC+SPC liposomes had the similar entrapment efficiency,size and zeta potential compared with the corresponding SPC liposomes.But the results of release profiles and leakage experiments revealed that the stability of ZTO-CD-loaded HSPC+SPC liposomes was significantly higher than that of SPC lipsomes.The LD50 values of ZTO solution,ZTO-CD,ZTO-CD-loaded SPC liposomes and ZTO-CD-loaded HSPC+SPC liposomes were 207.87,153.31,269.13 and 327.30 mg/kg following intravenous administration,respectively.CONCLUSION As to the carrier of ZTO,liposomes composed of both HSPC and SPC possess good stability and safety compared with conventional SPC liposomes." @default.
- W2365853859 created "2016-06-24" @default.
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- W2365853859 date "2012-01-01" @default.
- W2365853859 modified "2023-09-28" @default.
- W2365853859 title "Effect of phospholipid composition on pharmaceutical property and acute toxicity of liposomes entrapped zedoary turmeric oil and its inclusion" @default.
- W2365853859 hasPublicationYear "2012" @default.
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