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- W2365855226 abstract "Objective To investigate the effect of diallyl trisulfide(DATS)on tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)expression of lung tissue in mice with acute lung injury(ALI)induced by lipopolysaccharide(LPS).Methods ALI murine model was induced by injection of LPS.Mice were randomly divided into saline control group,ALI group,DATS prevention group,DATS treatment group,and DATS group.TNF-α and IL-1β levels in the supernatant of lung homogenates were detected by ELISA.The expression of TNF-α mRNA,IL-1β mRNA were detected with reverse transcription-PCR.Results The level of TNF-α and IL-1β in supernatant of lung homogenates increased markedly at 2h of ALI group(P0.01),and decreased at 6h,which were still higher than that of the control group(P0.01).The production of TNF-α and IL-1β induced by LPS could be reduced in DATS prevention group,but not changed in DATS treatment group.No significant mRNA expression of TNF-α and IL-1β were detected in the lung tissues of control group and DATS group mice.As expected,enhanced TNF-α and IL-1β mRNA expression was observed in the lungs of ALI group at 2 h(P0.01 vs control group),which were obviously declined in DATS prevention group(P0.05 vs ALI group).But in the DATS treatment group,the expression of TNF-α mRNA and IL-1β mRNA did not change significantly.Conclusion Preliminary administration of DATS could inhibit TNF-α and IL-1β production and mRNA expression in ALI mice." @default.
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- W2365855226 date "2007-01-01" @default.
- W2365855226 modified "2023-09-23" @default.
- W2365855226 title "EFFECT OF DIALLYL TRISULFIDE ON TNF-α AND IL-1β IN MICE WITH ACUTE LUNG INJURY INDUCED BY LIPOPOLYSACCHARIDE" @default.
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