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- W2365869300 abstract "Objective:To observe the changes of neurogliocytes in the brain of Alzheimer's disease(AD)rats which were treated with traditional Chinese medicine HuangQiSanXianTang(HQSXT)of BuShenHuoXue,and to investigate CNS immunoloregulation's mechanism of HQSXT for AD.Methods:Rats were randomly divided into groups.In model group and administration group,amyloid-beta protein(Aβ1-40)was microinjected into the right Meynert nucleus of rats.In administration group,the rats were treated with HQSXT.4 weeks later,ultrastructure of neurogliocyte was observed under transmission electron microscopy(TEM).Results:In model group,the TEM examination revealed lipofuscin and neurogliocytes hyperplasia reactively in the hippocampus,especially microglia,then asytrocyte.Microglia assembled and licked up degenerative neurons.Activated microglia masses were observed near blood vessel.In pseudo-operation group and administration group,neurogliocytes were observed too,but they are fewer than model group.These changes weren't be seen in control group,only a few lipofuscin were observed.Conclusion:The result of this study indicated that HQSXT could inhibit CNS Immunologic reaction and neurons's degeneration.And then could be used to treated AD." @default.
- W2365869300 created "2016-06-24" @default.
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- W2365869300 date "2005-01-01" @default.
- W2365869300 modified "2023-09-23" @default.
- W2365869300 title "Effect of Bushen HuoXue Fang on Neurogliocytes in AD Rats's Brain" @default.
- W2365869300 hasPublicationYear "2005" @default.
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