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- W2365883058 abstract "ObjectiveTo predict the secondary structures, B-cell epitopes and the HLA-A2 restricted cytotoxic T lymphocyte (CTL) epitope of tumor antigen MAGE-12. Methods The secondary structures of tumor antigen MAGE-12 were predicted by Garnier-Robson's method and the antigenic epitopes of B cells were analysed by using hydrophilicity plot. HLA-A2 restricted CTL epitopes of MAGE-12 were predicted by the method of simple motif and extended motif. Results MAGE-12 are rich in alpha helix;the epitope recognized by B cells may be at 3-14 or adjacent to 82-93;and one HLA-A2 restricted CTL epitope of tumor antigen MAGE-12 is at 271-279(FLWGPRALV). ConclusionB-cell epitopes and CTL epitope of MAGE-12 were predicted by using hydrophilicity approach and motif plots. The predicted epitopes provided useful hints to probe epitopes in MAGE-12 by experiments." @default.
- W2365883058 created "2016-06-24" @default.
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- W2365883058 date "2001-01-01" @default.
- W2365883058 modified "2023-09-26" @default.
- W2365883058 title "Predication of secondary structures and epitopes of tumor antigen MAGE-12" @default.
- W2365883058 hasPublicationYear "2001" @default.
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