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- W2365884238 abstract "Objective To explore the effects of oxymatrine(OMT) on injury induced by focal cerebral ischemia in rats and its mechanism.Methods Rats were randomly divided into sham(n=8),cerebral ischemia model(n=8),Lulu Tong(LLT,31.25 mg·kg-1,n=8) and OMT 35,70 and 105 mg·kg-1 groups(n=8).The focal cerebral ischemia was induced by middle cerebral artery occlusion in rats.The drugs were administrated by intraperitoneal injection.The neurological score and infarct volume were used to evaluate the protective effects of OMT in focal cerebral ischemia rats.The NO content in serum and myeloperoxidase(MPO) content in brain tissue were determined to study the its mechanisms.Results Compared with model group,the infarct volumes were decreased in OMT 35,70 and 105 mg·kg-1 groups(P0.05,P0.01,P0.001) and the neurological scores were decreased in OMT 70 and 105 mg·kg-1 groups(P0.01);The NO content in serum and MPO content in brain tissue in OMT groups were decreased(P0.05,P0.01).Conclusion OMT has protection against injury induced by cerebral ischemia in rats.The anti-inflammation effects may be one of the mechanisms." @default.
- W2365884238 created "2016-06-24" @default.
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- W2365884238 date "2008-01-01" @default.
- W2365884238 modified "2023-09-26" @default.
- W2365884238 title "Protective effects of oxymatrine on injury induced by focal cerebral ischemia in rats" @default.
- W2365884238 hasPublicationYear "2008" @default.
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