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- W2365896205 abstract "Objective Apoptosis may play a role in the neurodegenerative diseases. Accumulating evidences suggest that β-Amyloid contributes to neurodegeneration in Alzheimer disease, but the molecular mechanism responsible for neuronal loss in Alzheimer disease is not clear. We now report that β-Amyloid triggers the degeneration of cultured PC12 cell through activation of an apoptotic pathway. Methods Using DNA terminal-labelling, electric microscopy detected the morphological and bioche mical changes of cultured PC12 cells treated by Aβ. Results Morphological and biochemical characteri stics of apoptosis in cultured PC12 cells exposed in Aβ were exhibited, such as compaction of nuclear chromation, membrane blobbing, formation of apoptotic bodies and internuclear DNA fragmentation. Conclusion Our research suggests that apoptosis may play a role in neuronal losses associated Alzheimer disease." @default.
- W2365896205 created "2016-06-24" @default.
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- W2365896205 date "2000-01-01" @default.
- W2365896205 modified "2023-10-17" @default.
- W2365896205 title "The Study of Apoptosis in Cultured PC12 Cells Induced by β-Amyloid" @default.
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