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- W2365962692 abstract "Objective:To study rapid effect of corticosterone (CORT) on N-methy-D-asparatic acid (NMDA) receptor activity in hippocampal neurons in stress and to elucidate its underlying membrane mechanisms. Methods:Whole-cell patch-clamp recording was used to assess the effect of stressful concentration on the responses of cultured hippocampal neurons to glutamate and NMDA. To make clear the target of CORT, intracellular dialysis of CORT(10 μmol/L) through patch pipette and extracellular application of bovine serum albumin-conjugated corticosterone(CORT-BSA, 10 μmol/L)were carried out to observe their influence on peak amplitude of NMDA-evoked current. Results:CORT had a rapid, reversible and inhibitory effect on peak amplitude of Glu- or NMDA-evoked currents in cultured hippocampal neurons. Furthermore, CORT-BSA had the inhibitory effect on INMDA as corticosterone; but intracellu-larly dialyzed CORT had no significant effect on INMDA. Conclusion:These results suggest that under the condition of stress, CORT may rapidly, negatively regulate excitatory synaptic receptors-GluRs, especially NMDA receptor in central nervous system, which is mediated by rapid membrane mechanisms, but not by classical, genomic mechanisms." @default.
- W2365962692 created "2016-06-24" @default.
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- W2365962692 date "2006-01-01" @default.
- W2365962692 modified "2023-09-23" @default.
- W2365962692 title "Rapid effect of stressful concentration corticosterone on glutamate receptor and its subtype N-methyl-D-aspartate receptor activity in cultured hippocampal neurons" @default.
- W2365962692 hasPublicationYear "2006" @default.
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