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- W2365962867 abstract "The effects of DDPH on human and rabbit platelets aggregation and its mecha nisms were investigated. DDPH produced a dose-dependent inhibiton of rabbit platelets aggregation by ADP (IC50=5.8×10-4mol·L-1)and archidonic acid(AA). The human platelet aggregation induced by ADP and adrenaline (Adr) was inhibited by DDPH with IC50 value of 1.2 and 1.3×10-4 mol·L-1, respectively.The rabbit platelet aggregation induced by ADP and AA was inhibited with DDPH in vivo.DDPH(8 mg·kg-1 iv, 3 times/day×2) decreased TXB2 concentration in rabbit platelets and inhibited formation and release of TXB2 in activited rabbit platelets, but had no effect on concentration of 6-keto-PGF1α in plasma and arterial wall.The results indicate that DDPH has antiplatelet aggregation effect and its mechanisms may be relsted to the inhibition of platelet TXA2 formation and release,probably also to its adrenoreceptors blocking effect." @default.
- W2365962867 created "2016-06-24" @default.
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- W2365962867 date "1996-01-01" @default.
- W2365962867 modified "2023-09-23" @default.
- W2365962867 title "Effects of DDPH on human and rabbit platelet aggregation" @default.
- W2365962867 hasPublicationYear "1996" @default.
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