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- W2365982829 abstract "Objective:To exploit marine microorganisms and study their secondary metabolites for new drugs.Methods: An antibacterial model was used to screen for active strains. The ethyl acetate (EtOAc) extract was separated by silica chromatography, gel filtration chromatography, and high-performance liquid chromatography. The structures of the compounds were elucidated by 1HNMR, 13CNMR and MS technologies; Kirby-Bauer Disc Diffusion method and MTT method were employed to detect the biological activities of the separated compounds.Results: Eleven compounds were separated and identified as macrolactin A (1), 3-Hydroxyl acetyl-indole (2), 3-indolethanol (3), cyclo-(Try-Pro) (4), cyclo-(Ile-Try) (5), cyclo-(Leu-Pro) (6), cyclo-(Leu-Val) (7), cyclo-(Ile-Pro) (8), cyclo-(Phe-Val) (9), N-phenethylacetamide (10), P-hydroxy benzaldehyde (PHB) (11).Conclusion: Compound 1 shows strong inhibitory activities against Pyricularia oryzae, Escherichia coli and Staphylococcus aureus (with MIC values being 3.6, 0.45 and 6.3 μg/ml, respectively), and tumor cell lines HeLa and HepG2 (with the IC50 values being 2.0 and 1.8 μg/ml, respectively)." @default.
- W2365982829 created "2016-06-24" @default.
- W2365982829 creator A5066870388 @default.
- W2365982829 date "2008-01-01" @default.
- W2365982829 modified "2023-09-24" @default.
- W2365982829 title "Isolation,identification and biological characterization of secondary metabolites produced by a marine Bacillus subtilis" @default.
- W2365982829 hasPublicationYear "2008" @default.
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