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- W2365985190 abstract "Objective To explore the effect of Tongxinluo capsules on cortex angiogenesis and neuron apoptosis within focal cerebral ischemic rat brain. Methods Wistar rats were divided in two groups:control group and Tongxinluo capsule group and both subjected to MCAo surgery model. The immunohistochemistry was used to determine the VEGF,VIII factors and caspase-3 positive cells, Western blot to evaluate the expression level of VEGF and caspase-3 protein and TUNEL to quantify the apoptosis neuron cells in ischemic cortex. Results Compared with the control groups,Tongxinluo capsules significantly increased the vascular density and VEGF positive cell numbers(P 0.01). Western blots demonstrated prominence of two isoforms of VEGF protein, VEGF121 and VEGF165, in ipsilateral ischemic cortex but scarcity in contralateral cortex in both groups. Semi-quality analysis demonstrated that both levels of VEGF121 and VEGF165 were much higher in Tongxinluo groups than those in control groups(P 0.01). Fewer caspase-3 positive cells within ischemic cortex in Tongxinluo group were counted than those in the control group(P 0.01).In two groups, caspase-3 Western blot detected two bands corresponding to Pre-caspase-3 and activated caspase-3 within both ischemic ipsilateral and contrateral cortex. The untreated groups obtained the most expression of activated caspase-3 within ischemic cortex among all subgroups(P 0.01), but the expression of activated caspase-3 in Tongxinluo group failed to achieve the statistical significance either in its own control or compared with ischemic contralateral cortex of control groups(P 0.05). Moreover, the cortex TUNEL-positive cells in Tongxinluo group was much fewer than those in the control group(P 0.05). Conclusions Tongxinluo capsule can enhance angiogenesis within ischemic cortex by up-regulating the expression of VEGF protein, while can decrease neuron apoptosis, induced by ischemia and reperfusion injury, through preventing caspase-3 from being activated." @default.
- W2365985190 created "2016-06-24" @default.
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- W2365985190 date "2006-01-01" @default.
- W2365985190 modified "2023-09-23" @default.
- W2365985190 title "Effect of Tongxinluo capsules on cortex angiogenesis and neuron apoptosis in rats with focal cerebral ischemia" @default.
- W2365985190 hasPublicationYear "2006" @default.
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