Matches in SemOpenAlex for { <https://semopenalex.org/work/W2365998081> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2365998081 endingPage "363" @default.
- W2365998081 startingPage "357" @default.
- W2365998081 abstract "The study was aimed to investigate the human leukocyte antigen (HLA)-A, B, DRB1 alleles and haplotype frequencies and the characteristics of linkage disequilibrium in north Chinese Han bone marrow donors. HLA phenotype data of 11 755 north Chinese Han bone marrow donors were identified by PCR-SSP and PCR-SSO. HLA-A, B, DRB1 allele and haplotype frequencies were calculated by computer software named Arleguin which was based on Expectation-Maximization (EM) algorithms. The results showed that the population of 11755 unrelated-donors was tested by Hardy-Weinberg equilibrium, and 18,42 and 15 specificities of HLA alleles were identified on the HLA-A, B, DRB1 locus respectively, including HLA-A25, B42, B53, B73 and DR3 which were rarely reported in Han population. HLA-A36, A43, A80, B78, B82 and DR18 were not detected in this study. The most frequent alleles with a frequency of over 0.05 were HLA-A*02, A*11, A*24, A*33, A*30, A*01, A*03, A*13, B62, B*51, B*46, B60, B61, B*35, B*44, DRB1*15, DRB1*09, DRB1*04, DRB1*07, DRB1*12, DRB1*11, DRB1*14, DRB1*08, DRB1*13. There were a total of 2 026 kinds of HLA-A-B-DR haplotypes (with a frequency of over 10(-6)) to be obtained. The each frequency of 26 kinds of three-locus haplotypes including HLA-A30-B13-DR7, A2-B46-DR9, A33-B58-DR17 etc was higher than 0.005. A30-B13-DR7 was the most frequent haplotype in north Chinese Han population. There were a total of 538 kinds of haplotypes for HLA-A-B, 227 kinds for A-DR and 522 kinds for B-DR to be obtained, and there were 409, 195, 423 kinds of haplotypes respectively with a frequency higher than 10 - 6. There were 28 kinds of HLA-A-B haplotypes including A30-B13, A2-B46, A33-B58 etc, 26 kinds of HLA-A-DR haplotypes including A2-DR9, A2-DR15, A30-DR7 etc, and 24 kinds of HLA-B-DR haplotypes including B13-DR7, B46-DR9, B13-DR12 etc with a frequency higher than 0.01. 296 (72%) kinds of HLA-A-B, 130 (67%) kinds of A-DR and 308 (73%) kinds of B-DR haplotypes were statistical linkage disequilibrium. HLA-A30-B13, A33-B58, A1-B37, A30-DR7, A33-DR13, A1-DR10, B37-DR10, B8-DR17, B13-DR7, B58-DR17 were significant positive linkage disequilibrium. It is concluded that this HLA-A, B, DRB1 gene and haplotype frequencies and linkage disequilibrium data with the largest sample size up to now is unique in north Chinese Han population. The study will be helpful to find matched donors for patients and establish the important foundation for further studying of transplantation immunity, HLA-related diseases and population genetics of this area." @default.
- W2365998081 created "2016-06-24" @default.
- W2365998081 creator A5005685127 @default.
- W2365998081 creator A5048725056 @default.
- W2365998081 creator A5056691753 @default.
- W2365998081 creator A5072864302 @default.
- W2365998081 creator A5084835820 @default.
- W2365998081 creator A5086664284 @default.
- W2365998081 date "2007-04-01" @default.
- W2365998081 modified "2023-09-22" @default.
- W2365998081 title "[Gene and haplotype frequencies for the loci HLA-A, B and DRB1 in 11755 north Chinese Han bone marrow registry donors]." @default.
- W2365998081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17493347" @default.
- W2365998081 hasPublicationYear "2007" @default.
- W2365998081 type Work @default.
- W2365998081 sameAs 2365998081 @default.
- W2365998081 citedByCount "2" @default.
- W2365998081 countsByYear W23659980812015 @default.
- W2365998081 countsByYear W23659980812022 @default.
- W2365998081 crossrefType "journal-article" @default.
- W2365998081 hasAuthorship W2365998081A5005685127 @default.
- W2365998081 hasAuthorship W2365998081A5048725056 @default.
- W2365998081 hasAuthorship W2365998081A5056691753 @default.
- W2365998081 hasAuthorship W2365998081A5072864302 @default.
- W2365998081 hasAuthorship W2365998081A5084835820 @default.
- W2365998081 hasAuthorship W2365998081A5086664284 @default.
- W2365998081 hasConcept C104317684 @default.
- W2365998081 hasConcept C147483822 @default.
- W2365998081 hasConcept C180754005 @default.
- W2365998081 hasConcept C188280979 @default.
- W2365998081 hasConcept C197754878 @default.
- W2365998081 hasConcept C203014093 @default.
- W2365998081 hasConcept C2775866039 @default.
- W2365998081 hasConcept C2780007613 @default.
- W2365998081 hasConcept C2781142222 @default.
- W2365998081 hasConcept C2908647359 @default.
- W2365998081 hasConcept C35605836 @default.
- W2365998081 hasConcept C37463918 @default.
- W2365998081 hasConcept C54355233 @default.
- W2365998081 hasConcept C71924100 @default.
- W2365998081 hasConcept C84597430 @default.
- W2365998081 hasConcept C86803240 @default.
- W2365998081 hasConcept C99454951 @default.
- W2365998081 hasConceptScore W2365998081C104317684 @default.
- W2365998081 hasConceptScore W2365998081C147483822 @default.
- W2365998081 hasConceptScore W2365998081C180754005 @default.
- W2365998081 hasConceptScore W2365998081C188280979 @default.
- W2365998081 hasConceptScore W2365998081C197754878 @default.
- W2365998081 hasConceptScore W2365998081C203014093 @default.
- W2365998081 hasConceptScore W2365998081C2775866039 @default.
- W2365998081 hasConceptScore W2365998081C2780007613 @default.
- W2365998081 hasConceptScore W2365998081C2781142222 @default.
- W2365998081 hasConceptScore W2365998081C2908647359 @default.
- W2365998081 hasConceptScore W2365998081C35605836 @default.
- W2365998081 hasConceptScore W2365998081C37463918 @default.
- W2365998081 hasConceptScore W2365998081C54355233 @default.
- W2365998081 hasConceptScore W2365998081C71924100 @default.
- W2365998081 hasConceptScore W2365998081C84597430 @default.
- W2365998081 hasConceptScore W2365998081C86803240 @default.
- W2365998081 hasConceptScore W2365998081C99454951 @default.
- W2365998081 hasIssue "2" @default.
- W2365998081 hasLocation W23659980811 @default.
- W2365998081 hasLocation W23659980812 @default.
- W2365998081 hasOpenAccess W2365998081 @default.
- W2365998081 hasPrimaryLocation W23659980811 @default.
- W2365998081 hasRelatedWork W1537189563 @default.
- W2365998081 hasRelatedWork W174469790 @default.
- W2365998081 hasRelatedWork W1857013538 @default.
- W2365998081 hasRelatedWork W1975644316 @default.
- W2365998081 hasRelatedWork W1976558151 @default.
- W2365998081 hasRelatedWork W1981116029 @default.
- W2365998081 hasRelatedWork W1984146422 @default.
- W2365998081 hasRelatedWork W1984383566 @default.
- W2365998081 hasRelatedWork W1986907664 @default.
- W2365998081 hasRelatedWork W2028151227 @default.
- W2365998081 hasRelatedWork W2073602693 @default.
- W2365998081 hasRelatedWork W2089578437 @default.
- W2365998081 hasRelatedWork W2147774390 @default.
- W2365998081 hasRelatedWork W2337471386 @default.
- W2365998081 hasRelatedWork W2352518078 @default.
- W2365998081 hasRelatedWork W2355074688 @default.
- W2365998081 hasRelatedWork W2360774964 @default.
- W2365998081 hasRelatedWork W2509726029 @default.
- W2365998081 hasRelatedWork W2808099727 @default.
- W2365998081 hasRelatedWork W76739205 @default.
- W2365998081 hasVolume "15" @default.
- W2365998081 isParatext "false" @default.
- W2365998081 isRetracted "false" @default.
- W2365998081 magId "2365998081" @default.
- W2365998081 workType "article" @default.