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- W2366008708 abstract "AIM To study the pharmacokinetics and human bioavailability of omeprazole. METHOD Ten male healthy volunteers orally took domestic omeprazole entero dissolving capsules and Losec entero dissolving capsules(used as reference ) 20 mg respectively. Blood concentrations of two drugs were tested with HPLC. RESULTS Data were processed by using 3P87 program. The plasma concentration time curves of these two drugs appeared to fit oral first order absorption and one compartment open model. The pharmacokinetic parameters of omeprazole are as follows: T 12 is (1 68±1 05) h, T max is (1 94±0 23) h, C max is ( 1 157 ±592) nmol·L -1 ,AUC is (3 998 95±2 207 27) nmol·L -1 ·h -1 ,CL/ F is (18 54±8 26)L, V/F is (38 40±19 27)L. The relative bioavailability of omeprazole entero dissolving capsule is 92 09%±12 00%. CONCLUSION After analysis, these two drugs have the same bioequivalence." @default.
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- W2366008708 date "1998-01-01" @default.
- W2366008708 modified "2023-09-25" @default.
- W2366008708 title "Study on the pharmacokinetics and human bioavailability of omeprazole" @default.
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