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- W2366020181 abstract "AIM:To reveal characteristics and evolutions of PB2 genes of human avian H5N1 influenza strains by analysis on sequences of PB2 gene.METHODS:The PB2 gene of human avian H5N1 influenza in Guangdong was sequenced and the global PB2 genes of strains were searched out from internet.They were analyzed by DNAStar 5.0 by means of studying the revolutionary speeds combining the epidemiological data.RESULTS:PB2 genes of 48 strains during 1997-2006 were homologously classified into two groups:strains during 1997-1998(G1),strains during 2003-2006(G2).There were 101 substitutions of amino acids in PB2 in all strains,accounting for 13.3%(101/759).In the variation,Kss in PB2 were 39.4×10-6～63.4×10-6 Nt/d and Kas in PB2 were 3.36×10-6～5.11×10-6 Nt/d,which indicated that evolution of PB2 genes obviously resulted from spontaneously mutation.The PB2 genes of strains during 2003-2006(including GD-01-06)only remained a glycoprotein domain(NPT301-303)and deleted other three glycoprotein domains,which might have an impact on the strain pathogenicity.CONCLUSION:PB2 genes are classified into two groups and they evolve rapidly in genes by spontaneously mutation.The deletion of three glycoprotein domains in PB2 genes might result in variation of the strain pathogenicity,including the probability of human-human transmission and initiating a new pandemic of human avian H5N1 influenza." @default.
- W2366020181 created "2016-06-24" @default.
- W2366020181 creator A5058318523 @default.
- W2366020181 date "2007-01-01" @default.
- W2366020181 modified "2023-09-26" @default.
- W2366020181 title "Evolutions and characteristics on PB2 gene of human avian H_5N_1 strain in Guangdong" @default.
- W2366020181 hasPublicationYear "2007" @default.
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