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- W2366023205 abstract "Objective To study the protective effect of PPARγ agonist on the ischemia-reperfusion injury of brain tissue and the expression of PPARγ.Methods Adult male SD rats were randomly divided into the following groups:sham+NS group,I/R+NS group,I/R+PGZ(low dose,10mg/kg·d) group,I/R+PGZ(large dose,15mg/kg·d) group.Infarct volume(by TTC dyeing),mRNA and protein expression of PPARγ(by RT-PCR and western blotting) were measured at 24h after termination of ischemia.Results PPARγ agonists(PGZ) could significantly reduce the cerebral infarction volume,and the effection of large dose intervention group was more predominant than that of low dose intervention group.PGZ had no influence on blood glucose,serum triglyceride,serum total cholesterol,serum insulin and SBP level.PPARγ agonists(PGZ) could upregulate the expression of PPARγ mRNA and protein,and the level increased along with the dosage of pioglitazone.Conclusions PPARγ agonists could enhance the expression of PPARγ mRNA and protein in the ischemia-reperfusion cerebral tissues,and as the interventional doses increased,the protection to ischemic brain tissues enhanced with the upregulation of the expression of PPARγ.From above,we conclude that there is protective significances in of giving PPARγ agonistsreducing ischemia-reperfusion injury of cerebral tissues." @default.
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- W2366023205 date "2007-01-01" @default.
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- W2366023205 title "The protective effects of PPARγ agonist on the ischemia-reperfusion injury of brain and the expression of PPARγ" @default.
- W2366023205 hasPublicationYear "2007" @default.
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